Sjögren’s Syndrome
Treatment in Singapore
Sjögren’s syndrome is a chronic autoimmune disease characterised by the body’s immune system mistakenly attacking its own moisture-producing glands. This leads to dryness of the mouth and eyes, among other symptoms. The condition primarily affects middle-aged women but can occur in people of any age or gender. Understanding Sjögren’s syndrome involves exploring its symptoms, causes, diagnosis, treatment, and impact on patients’ lives.
Symptoms of Sjögren’s Syndrome
Sjögren’s syndrome has a wide range of symptoms, which can be categorised into primary and secondary manifestations. The severity and combination of symptoms can vary significantly from person to person.
Common symptoms include:
Primary Symptoms
- Dry Mouth (Xerostomia) – A lack of saliva production leads to difficulty swallowing, speaking, and an increased risk of dental decay and oral infections.
- Dry Eyes (Keratoconjunctivitis Sicca) – Insufficient tear production causes irritation, burning, a gritty sensation, and potential damage to the cornea.
Secondary Symptoms
- Swollen Salivary Glands – Particularly the glands located in front of the ears (parotid glands), leading to swelling and discomfort.
- Dry Skin – Generalized dryness, itching, and scaling of the skin.
- Dryness of Other Mucous Membranes – This includes the nose, throat, and vaginal dryness in women.
- Fatigue – A common and often debilitating symptom affecting the overall quality of life.
- Joint and Muscle Pain – Stiffness, pain, and swelling in the joints and muscles.
- Other Organ Involvement – In some cases, Sjögren’s syndrome can affect the kidneys, liver, lungs, pancreas, and nervous system, leading to a range of systemic symptoms.
Causes and Risk Factors of Sjögren’s Syndrome
The exact cause of Sjögren’s syndrome is not fully understood, but it is believed to involve a combination of genetic, environmental, and hormonal factors.
Genetic Factors
- Family History – Having a relative with Sjögren’s syndrome or another autoimmune disease increases the risk.
- Genetic Predisposition – Certain genetic markers and genes have been associated with a higher risk of developing Sjögren’s syndrome.
Environmental Factors
- Viral Infections – Some researchers suggest that infections with certain viruses might trigger the autoimmune response that leads to Sjögren’s syndrome.
Hormonal Factors
- Gender and Hormones – The condition predominantly affects women, suggesting that female hormones may play a role in its development.
Diagnosis
Diagnosing Sjögren’s syndrome can be challenging due to its broad range of symptoms and overlap with other autoimmune diseases. A combination of clinical evaluation, laboratory tests, and imaging studies is typically used.
Diagnosis methods include:
Clinical Evaluation
- Medical History – A detailed medical history to identify symptoms and their progression, along with any family history of autoimmune diseases.
- Physical Examination – Examination of the eyes, mouth, and other affected areas for signs of dryness and swelling.
Laboratory Tests
- Blood Tests – To detect specific autoantibodies, such as anti-Ro/SSA and anti-La/SSB, and to measure markers of inflammation like ESR and CRP.
- Salivary Gland Tests – Sialometry to measure saliva production and biopsy of the minor salivary glands to look for characteristic inflammatory cells.
Imaging Studies
- Schirmer’s Test – To measure tear production and assess the severity of dry eyes.
- Salivary Gland Scintigraphy – A nuclear medicine test to evaluate the function of the salivary glands.
- Ultrasound or MRI – Imaging studies to assess the structure and function of the salivary glands and detect any abnormalities.
Sjögren’s Syndrome Treatment
There is no cure for Sjögren’s syndrome, but treatment focuses on managing symptoms and preventing complications. Treatment plans are tailored to the individual’s specific symptoms and disease severity.
Medications
- Artificial Tears and Saliva Substitutes – To relieve dryness of the eyes and mouth.
- Immunosuppressants – These drugs are used to reduce the immune system’s activity and manage systemic symptoms.
- Corticosteroids – Used for short-term management of severe inflammation.
- Cevimeline – Medication that stimulates saliva and tear production.
Physical and Occupational Therapy
- Exercise Programs – Designed to maintain joint mobility and muscle strength.
- Moisture-Protecting Measures – Using humidifiers and avoiding environments that exacerbate dryness.
Lifestyle Modifications
- Hydration – Drinking plenty of fluids to help manage dryness symptoms.
- Dental Care – Regular dental check-ups and good oral hygiene to prevent complications from dry mouth.
- Diet and Nutrition – A balanced diet to support overall health and manage gastrointestinal symptoms.
Sjögren’s syndrome is a complex autoimmune disease with many symptoms affecting moisture-producing glands and other organs. Early diagnosis and a tailored, multidisciplinary approach to treatment are crucial for managing symptoms and improving quality of life. While there is no cure, ongoing research aims to understand the disease better and develop more effective treatments. Patients with Sjögren’s syndrome can benefit greatly from a comprehensive care plan that addresses both the physical and emotional aspects of the disease.
Manage Sjögren’s Syndrome
with Dr Anindita Santosa
Persistent dryness may appear to be limited to the eyes or mouth, yet Sjögren’s syndrome can also contribute to fatigue, joint or muscle pain and, in some cases, organ involvement. A comprehensive evaluation helps connect these symptoms, assess gland function and establish whether an autoimmune condition is responsible. Tailored care can relieve dryness, protect eye and oral health, and monitor for wider complications.
At Aaria Rheumatology, care reflects the combination and severity of symptoms affecting each patient. Rheumatologist Dr Anindita Santosa reviews your medical history, examination findings, antibody tests, and tear or saliva assessments before recommending an individualised management plan.
If you have ongoing dry eyes or mouth, swollen salivary glands, unexplained fatigue or joint discomfort, contact us today to book an appointment.
